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Mussafia, dans Romania , 18, , p. Bourciez, dans Revue des langues romanes , 74, , p. Runnalls, dans French Studies , 27, , p. Claude Buridant, dans Revue de linguistique romane , 55, , p. Muller, dans Speculum , Muir, dans French Studies , 28, , p. Axton, dans Medium Aevum , 49, , p.
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Runnalls, dans Modern Language Review , 69, , p. Product details? The Ethics of Altruism. Michel Onfray? A Handbook of Transcription Factors Targeted Drug Strategies for Cancer and Inflammation Transcription factors are the molecules that the cell uses to interpret the genome: In aggregate, transcription factors control gene expression and genome organization, and play a pivotal role in many aspects of physiology and evolution.
This book provides a reference for major aspects of transcription factor function, encompassing a general catalogue of known transcription factor classes, origins and evolution of specific transcription factor types, methods for studying transcription factor binding sites in vitro, in vivo, and in silico, and mechanisms of interaction with chromatin and RNA polymerase. Features Transcription factors are - in the most common use of the term - proteins that possess sequence-specific DNA-binding activity, and either directly or indirectly influence the transcription of genes in proximity to the binding site.
Transcription factors are the primary interface between the cell and the genome, and in aggregate control not only regulation of transcription but also genome organization, and play [.. Weirauch and Timothy R. Antifolate drugs that are largely transported via a high capacity folate transporter i. Major advances in folate research made within the last decade include i the approval of pemetrexed for the treatment of lung cancer and mesothelioma, and ii the demonstration that cell membrane-anchored folate receptors FR are exploitable for cancer and inflammatory disease management.
FRs are not widely distributed in normal tissues, except on some luminal surfaces; however, they are accessible to systemically administered agents when expressed on many cancers as well as on activated macrophages involved in various inflammatory diseases. High affinity folate-radioisotope conjugates have been developed for imaging pathogenic FR-positive[.. With 1 4-page color insert.
NF-kB in Health and Disease Nearly 25 years of intensive research have uncovered many diverse functions for the dimeric transcription factor known as NF-kappaB nuclear factor-kappaB.
NF-kappaB affects most aspects of cellular physiology—from immunity and inflammation to apoptosis, cell survival, growth, and proliferation Features This volume is focused on a transcription factor that started its life as a B cell-specific nuclear protein, but has matured to become one of the most extensively studied transcriptional regulators, found to control many pathophysiological processes: Articles in the volume, all of them written by the leading experts in the field, range from description of the NF-kB system and its basic components, [..
Current Topics in Microbiology and Immunology, Vol. Mitochondrial Dynamics and Neurodegeneration Chemistry, Biology and Physics Over the last few years, bacterial adhesion has become a more and more important and active scientific area, but the field lacks communication and scientific exchange between medical and microbiology researchers who work with the relevant biological systems, and biochemists, structural biologists and physicists, who know and understand the physical methods best suited to investigate the phenomenon at the molecular level.
The field consequently would benefit from a cross-disciplinary conference enabling such communication. This book tries to bridge the gap between the disciplines. Features Adhesion plays a major role in the bacterial lifestyle. Bacteria can adhere to organic and inorganic surfaces, to each other, and of course to host cells during pathogenesis.
The focus of this book is: Microbial genetics experiments have greatly enhanced our knowledge of what bacterial factors are involved in adhesion. For numerous reasons, though, [..
Adhesins of human pathogens from the genus Yersinia; 2. Adhesive mechanisms of Salmonella enteric; 3. Adhesion Mechanisms of Borrelia burgdorferi; 4.
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Adhesins of Bartonella spp. Adhesion Mechanisms of Plant-Pathogenic Xanthomonadeae; 6. Adhesion by Pathogenic Corynebacteria; 7. Viral Vectors for Gene Therapy Methods and Protocols Mitochondria are essential organelles in eukaryotic cells that control such diverse processes as energy metabolism, calcium buffering, and cell death. Recent studies have revealed that changes in mitochondrial morphology by fission and fusion, a process known as mitochondrial dynamics, is particularly important for neuronal function and survival.
Defects in this process are commonly found in neurodegenerative diseases, offering a new paradigm for investigating mechanisms of neurodegeneration. To provide researchers working on neurodegenerative diseases and mitochondria with updated information on this rapidly progressing field, we have invited experts in the field to critically review recent progresses and identify future research directions. Features Mitochondria are essential organelles in eukaryotic cells that control such diverse processes as energy metabolism, calcium buffering, and cell death. Recent studies have revealed that changes in mitochondrial morphology by fission and fusion, a process known as mitochondrial dynamics, is particularly important for the function and survival of neurons.
Defects in this process are commonly found in [.. In Viral Vectors for Gene Therapy: Methods and Protocols, experts in the field present a collection of their knowledge and experience featuring methodologies that involve virus production, transferring protocols, and evaluating the efficacy of gene products. While thoroughly covering the most popular viral vector systems of adenovirus, retrovirus, and adeno-associated virus, this detailed volume also explores less common viral vector systems such as baculovirus, herpes virus, and measles virus, the growing interest in which is creating a considerable demand for large scale manufacturing and purification procedures.
Methods and Protocols, experts in the field present a collection of their knowledge and [.. Genetics of mitochondrial fission and fusion; 2.
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Relationship between mitochondrial dynamics and bioenergetics; 3. Mitochondrial dynamics and autophagy; 4. Mitochondrial dynamics and apoptosis; 5. Mitochondrial dynamics and axonal transport; 6. Mutations in mitochondrial fusion machinery linked to neurological diseases; 7. Contents Introduction to Viral Vectors. Production and Purification of Helper Dependent Adenovirus. Invariants of Behavior Brain, Behavior and Epigenetics Constancy and Variability in Neural Systems Whole new areas of immunological research are emerging from the analysis of experimental data, going beyond statistics and parameter estimation into what an applied mathematician would recognise as modelling of dynamical systems.
Stochastic methods are increasingly important, because stochastic models are closer to the Brownian reality of the cellular and sub-cellular world. The study of the brain and behavior is illuminated with the discovery of invariances. Experimental brain research uncovers constancies amidst variation, with respect to interventions and transformations prescribed by experimental paradigms.
Place cells, mirror neurons, event related potentials and areas differentially active in fMRI, all illustrate the pervasive role of invariances in neural systems in relation to their function. Features Mathematical immunology is in a period of rapid expansion and excitement. At recent meetings, a common language and research direction has emerged amongst a world-class group of scientists and mathematicians.
Mathematical Models and Immune Cell Biology aims to communicate these new ideas to a wider audience. The reader will be exposed to a variety of tools and methods that go hand-in-hand with the [..
Experimental brain research uncovers constancies amid variation with respect to interventions and transformations prescribed by experimental paradigms; furthermore, place cells, mirror neurons, event-related potentials, and areas differentially active in fMRI all illustrate the pervasive role of invariances in neural systems in [.. Constancy and Variability in Neural Systems and Behavior. The reasons for this are numerous, but primarily it stems from the mounting realization that research programs focused solely on DNA sequence variation, despite their breadth and depth, are unlikely to address all fundamental aspects of human biology.
Some questions are evident even to non-biologists. How does a single zygote develop into a complex multicellular organism composed of dozens of different tissues and hundreds of cell types, all genetically identical but performing very different functions? Why do monozygotic twins, despite their stunning external similarities, often exhibit significant differences in personality and predisposition to disease?
see url If environmental factors are solely the cause of such variation, why are similar differences also observed between genetically identical animals housed in a uniform environment? Over the last couple of decades, epigenetics has[.. How do the [.. Post-translational histone modifications and the neurobiology of psychosis. Epigenetic regulation of GABAergic targets in psychiatry. Possible roles of DNA methylation in bipolar disorder.